Difference between revisions of "APTX 4869"
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It is to note that in the instances where Shinichi or Shiho were successfully changed back, the recipient was suffering from a common cold while the component was ingested, indicating that the immune system somehow has to be taxed for the antidote to work.<ref>Manga Chapters 092-095: The Great Detective of the West</ref><ref>Manga Chapter 241: The Bullet from the Past</ref><ref>Manga Chapters 255-257: The School Play Case</ref> While not canon, ''[[Crossroad in the Ancient Capital]]'' uses this idea as Conan is given a pill to give him the symptoms of a cold, while drinking Baigar. | It is to note that in the instances where Shinichi or Shiho were successfully changed back, the recipient was suffering from a common cold while the component was ingested, indicating that the immune system somehow has to be taxed for the antidote to work.<ref>Manga Chapters 092-095: The Great Detective of the West</ref><ref>Manga Chapter 241: The Bullet from the Past</ref><ref>Manga Chapters 255-257: The School Play Case</ref> While not canon, ''[[Crossroad in the Ancient Capital]]'' uses this idea as Conan is given a pill to give him the symptoms of a cold, while drinking Baigar. | ||
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| + | Though no explanation was given, Conan and Haibara briefly reverted to their true age while having rum cake in ''[[Shinichi Kudo Returns! Confrontation with the Black Organization]]''. | ||
== References == | == References == | ||
Revision as of 10:20, 21 September 2010
APTX 4869 (四八六九 Yon-Hachi-Roku-Kyuu), code-named Prototype Detective, is a fictional toxin and derivative of an experimental immortality formula developed by Shiho Miyano, which is used by the Black Organization as an untraceable, lethal poison.
APTX is an abbreviation of "Apoptoxin," and, as the name implies, it involves the activation of uncontrolled apoptosis which causes death by the destruction of cells. In addition, it can also activate telomerase. The original purpose of the compound, as hinted by Haibara herself, is "to raise the dead", indicating an intent to control biological life.[1]
However, in very rare cases, it causes the apoptosis of non-neural cells only and the apoptosis would stabilize at some point, causing the victim's apparent age to be decreased. Shinichi, the series' protagonist, is such a victim; later Shiho Miyano, who chooses to attempt suicide by using her own drug, was added to the two known people to have survive after taking the APTX-4869 throughout the series.
Reversing the effects
Throughout the series there are several instances in which the APTX was temporarily neutralized and Shinichi and Shiho were returned to their actual age forms. The main ingredient for this reversal is a component found in Chinese ginseng root schnaps, which Ai has already incorporated in a prototype antidote for the APTX.[2]
It is to note that in the instances where Shinichi or Shiho were successfully changed back, the recipient was suffering from a common cold while the component was ingested, indicating that the immune system somehow has to be taxed for the antidote to work.[3][4][5] While not canon, Crossroad in the Ancient Capital uses this idea as Conan is given a pill to give him the symptoms of a cold, while drinking Baigar.
Though no explanation was given, Conan and Haibara briefly reverted to their true age while having rum cake in Shinichi Kudo Returns! Confrontation with the Black Organization.
